Patching in Children With Unilateral Congenital Cataract and Child Functioning and Parenting Stress.

Importance: Parents may be concerned about the adverse outcomes of occlusion therapy in children treated for unilateral congenital cataract (UCC). Objective: To determine whether occlusion therapy in children treated for UCC with poor visual outcomes is negatively associated with poorer child and/or family functioning. Design, Setting, and Participants: This cohort study was conducted in 2023 using data collected between 2006 and 2016 in the Infant Aphakia Treatment Study (IATS). IATS participants with a visual acuity (VA) of 20/200 or worse were included. Statistical analysis was performed from July 2022 to October 2023. Exposure: Caregivers reported the mean daily minutes of patching during the 12 months prior to the VA assessment at 4.5 years of age. Patching was categorized as minimal (<15 minutes per day), moderate (15 to <120 minutes per day), or extensive (≥120 minutes per day). Main Outcome Measures: At 4.25 and 10.5 years of age, caregivers reported stress associated with the parenting role using the Parenting Stress Index and the Ocular Treatment Index and child behavior problems using the Achenbach Child Behavior Checklist. Motor skills were assessed at age 54 months using the Movement Assessment Battery for Children-Second Edition. Children completed the Harter Self-Perception Profile for Children at age 10.5 years. One-way analysis of variance and χ2 tests were used to compare outcomes by amount of patching. Results: Patching data were available for 47 of 53 children (88.7%) with a VA of 20/200 or worse. Among these 47 children with patching data included in the study, 20 (42.5%) were female, 27 (57.5%) were male, 12 (25.5%) were reported to have been patched fewer than 15 minutes per day, 11 (23.4%) were patched 16 to 119 minutes per day, and 24 (51.1%) were patched at least 120 minutes per day. Parenting stress, child behavior problems, motor functioning, and child self-perception were similar in all groups. For example, after adjusting for gender and insurance status, there was a nonsignificant difference between mean stress scores of 11.0 (95% CI, -4.5 to 26.5) points for parents who reported minimal patching vs parents who reported patching at least 120 minutes per day, and there was no significant difference in children's report of their global self-worth (0.0 [95% CI, -0.4 to 0.3] points). Conclusions and Relevance: Occlusion therapy was not negatively associated with family or child functioning. Although the sample size was limited, these results do not support changes to the current practice guidelines.

Exploring Disability as a Determinant of Girl Child Marriage in Fragile States: A Multicountry Analysis.

PURPOSE: Fragile states are countries characterized by poverty, conflict, political instability, insecurity, and disaster. In such settings, there are high levels of disability and women and girls are disproportionately impacted by violence. Despite the 2030 Sustainable Development Goal's call for both the elimination of violence against women and girls and disability-disaggregated data, few studies have investigated how disability may be associated with girl child marriage (GCM) and how these two factors impact intimate partner violence (IPV). This study sought to assess the prevalence and associations of disability with GCM and IPV among currently married/cohabiting women (aged 20-24 years) in fragile states. METHODS: A secondary data analysis of pooled nationally representative data from four Demographic and Health Surveys were analyzed using multivariable regressions to examine the associations between disability, GCM, and IPV (N = 3,119). The association between disability and GCM was further analyzed by multinomial regressions. These weighted analyses accounted for complex survey designs. RESULTS: Overall, 54.4% of GCM occurred among women with disabilities. Disabled women were more likely to report GCM compared to women without disabilities (adjusted odds ratio = 1.62, 95% confidence interval = 1.16-2.28). Among disabled women with a history of GCM, 41.3% experienced past-year IPV. Disabled women with a history of GCM were more likely to report past-year IPV compared to nondisabled women and no GCM (adjusted odds ratio = 1.78, confidence interval = 1.21-2.62). DISCUSSION: GCM and IPV (e.g., past-year, lifetime) among disabled girls may be pervasive in fragile states, underscoring the need for additional research examining the mechanisms driving these observations and to inform inclusive programming and policy.

Disability and intimate partner violence in fragile states: A multi-country analysis.

The 2030 Sustainable Development Goals call for both the elimination of violence against women and girls and disability-disaggregated data. However, few population-based, multi-country studies have examined how disability impacts intimate partner violence (IPV) in fragile settings. Demographic and Health Survey data from five countries (Pakistan, Timor-Leste, Mali, Uganda, and Haiti) were pooled and analyzed to assess the relationship between disability and IPV (N = 22,984). Pooled analysis revealed an overall disability prevalence of 18.45%, with 42.35% lifetime IPV (physical, sexual and/or emotional), and 31.43% past-year IPV. Women with disabilities reported higher levels of past-year and lifetime IPV compared to those without disabilities (AOR 1.18; 95% CI 1.07, 1.30; AOR 1.31; 95% CI 1.19, 1.44, respectively). Women and girls with disabilities may be disproportionately impacted by IPV in fragile settings. More global attention is needed to address IPV and disability in these settings.

The association between women's disability and acceptance towards intimate partner violence among women and their male partners: A multi-country analysis.

OBJECTIVE: To examine whether disabled women are more likely to report accepting attitudes towards intimate partner violence (IPV) than non-disabled women, and whether male partners of disabled women are more likely to accept IPV than male partners of non-disabled women. METHODS: Secondary analysis of nationally representative cross-sectional data from the Demographic Health Survey (DHS) in nine countries. Logistic regression examined the relationship between (1) women's disability and IPV acceptance (n = 114 695) and (2) women's disability and their male partners' IPV acceptance (n = 20 566); pooled and country-specific estimates were calculated. RESULTS: IPV acceptance ranged from 5% to 80% among women and from 5% to 56% among male partners. Overall, disabled women were more accepting of IPV than non-disabled women (pooled adjusted odds ratio [aOR] 1.14, 95% confidence interval [CI] 1.08-1.20), with country-specific aOR ranging from 1.05 to 1.63. Overall, disabled women's male partners had higher likelihood of IPV acceptance than non-disabled women's partners (pooled aOR 1.13, 95% CI 1.00-1.28).; country-specific estimates varied (aOR range from 0.56 to 1.40). CONCLUSION: Disabled women and their male partners had higher IPV acceptance compared with non-disabled women and their male partners. More research is needed to better understand this association, including disability-associated discrimination. Findings underscore the importance of more research with disabled women and their partners to address IPV.

On the identification of individual level pleiotropic, pure direct, and principal stratum direct effects without cross world assumptions.

The analysis of natural direct and principal stratum direct effects has a controversial history in statistics and causal inference as these effects are commonly identified with either untestable cross world independence or graphical assumptions. This article demonstrates that the presence of individual level natural direct and principal stratum direct effects can be identified without cross world independence assumptions. We also define a new type of causal effect, called pleiotropy, that is of interest in genomics, and provide empirical conditions to detect such an effect as well. Our results are applicable for all types of distributions concerning the mediator and outcome.

Dramatic increase in HIV prevalence after scale-up of antiretroviral treatment.

OBJECTIVES: To investigate HIV prevalence trends in a rural South African community after the scale-up of antiretroviral treatment (ART) in 2004. METHODS: We estimated adult HIV prevalence (ages 15-49 years) using data from a large, longitudinal, population-based HIV surveillance in rural KwaZulu-Natal, South Africa, over the period from 2004 (the year when the public-sector ART scale-up started) to 2011. We control for selection effects due to surveillance nonparticipation using multiple imputation. We further linked the surveillance data to patient records from the local HIV treatment program to estimate ART coverage. RESULTS: ART coverage of all HIV-infected people in this community increased from 0% in 2004 to 31% in 2011. Over the same observation period adult HIV prevalence increased steadily from 21 to 29%. The change in overall HIV prevalence is nearly completely explained by an increase of HIV-infected people receiving ART, and it is largely driven by increases in HIV prevalence in women and men older than 24 years. CONCLUSION: The observed dramatic increase in adult HIV prevalence can most likely be explained by increased survival of HIV-infected people due to ART. Future studies should decompose HIV prevalence trends into HIV incidence and HIV-specific mortality changes to further improve the causal attribution of prevalence increases to treatment success rather than prevention failure.

High coverage of ART associated with decline in risk of HIV acquisition in rural KwaZulu-Natal, South Africa.

The landmark HIV Prevention Trials Network (HPTN) 052 trial in HIV-discordant couples demonstrated unequivocally that treatment with antiretroviral therapy (ART) substantially lowers the probability of HIV transmission to the HIV-uninfected partner. However, it has been vigorously debated whether substantial population-level reductions in the rate of new HIV infections could be achieved in "real-world" sub-Saharan African settings where stable, cohabiting couples are often not the norm and where considerable operational challenges exist to the successful and sustainable delivery of treatment and care to large numbers of patients. We used data from one of Africa's largest population-based prospective cohort studies (in rural KwaZulu-Natal, South Africa) to follow up a total of 16,667 individuals who were HIV-uninfected at baseline, observing individual HIV seroconversions over the period 2004 to 2011. Holding other key HIV risk factors constant, individual HIV acquisition risk declined significantly with increasing ART coverage in the surrounding local community. For example, an HIV-uninfected individual living in a community with high ART coverage (30 to 40% of all HIV-infected individuals on ART) was 38% less likely to acquire HIV than someone living in a community where ART coverage was low (<10% of all HIV-infected individuals on ART).